Multimodal neuroprotective therapy with induced hypothermia after ischemic stroke.
نویسندگان
چکیده
Neuroprotective therapies have so far failed to provide improved neurological function and outcome after stroke. A recent focus on multimodal therapies, including the combination of neuroprotective medications with hypothermia, opens a promising new treatment strategy. Advances in hypothermia administration make it one of the most promising neuroprotective therapies available and an ideal candidate for combination with other neuroprotective approaches.
منابع مشابه
Delayed combination therapy of local brain hypothermia and decompressive craniectomy on acute stroke outcome in rat
Objective(s):Hypothermia and decompressive craniectomy (DC) have been shown to be neuroprotective. This study was designed to evaluate neuroprotective effects of delayed singular or combination of DC and local hypothermia on stroke. Materials and Methods: Cerebral ischemia was induced in 48 Wistar rats assigned to 4 groups: control, decompressive craniectomy (DC), local hypothermia (LH), combin...
متن کاملCombination of Therapeutic Hypothermia and Other Neuroprotective Strategies after An Ischemic Cerebral Insult#
Abrupt deprivation of substrates to neuronal tissue triggers a number of pathological events (the "ischemic cascade") that lead to cell death. As this is a process of delayed neuronal cell death and not an instantaneous event, several pharmacological and non-pharmacological strategies have been developed to attenuate or block this cascade. The most promising neuroprotectant so far is therapeuti...
متن کاملTherapeutic hypothermia for acute ischemic stroke.
Intravenous recombinant tissue plasminogen activator remains the only US FDA-approved treatment for acute ischemic stroke. However, the very limited time window for its administration restricts its usefulness. Furthermore, it is becoming increasingly clear that, given the numerous pathways via which cerebral ischemia causes cell death, the capacity to inhibit multiple mechanisms simultaneously ...
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Background and purpose: Both hypothermia and Decompressive craniectomy (DC) have been shown to reduce ischemic injury in experimental middle cerebral artery occlusion (MCAO). This study was designed to evaluate the effect of delayed combination of DC and Local Hypothermia (LH) on infarct size, neurological outcome and blood brain barrier (BBB) disruption in a rat model of stroke. Material a...
متن کاملبررسی اثر هیپوترمی جنرال بر سکته مغزی مدل آمبولیک در موش صحرایی نر
Introduction: Hypothermia has neuroprotective effects in permanent or transient models of cerebral artery occlusion. In the current study, neuroprotective effect of general hypothermia in the embolic model of stroke, in which no study has been conducted to date. Methods: In this experimental study, twenty-four male Wistar rats (250 to 350 g) were divided into three groups as following: sha...
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ورودعنوان ژورنال:
- Stroke
دوره 40 3 Suppl شماره
صفحات -
تاریخ انتشار 2009